Proven Safety Profile

nine years prospective data badge

“Responsive neurostimulation was well tolerated and safe over time.”

Conclusions from 9 years of data in the largest prospective neuromodulation study in the field of epilepsy1

Neurology, 2020

Read More About the Long-Term Data

The RNS® System Has No Chronic Stimulation
Side Effects1

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Side effects seen with DBS2,3:

  • Depression
  • Anxiety
  • Memory Impairment
  • Sleep Disruption
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Side effects seen with VNS4:

  • Voice alterations
  • Throat pain and cough
  • Shortness of breath
  • Difficulty swallowing
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“The RNS System basically functions in the background for me. As I go about my daily life, I do not feel any physical or mental sensations from its electrical signals.”


Lower SUDEP Rates with the RNS System

Each year, 1 in 150 people with uncontrolled seizures die from Sudden Unexpected Death in Epilepsy (SUDEP).5

Patients treated with the RNS System have a statistically significantly lower rate of SUDEP than a comparable refractory population.1

Read More About Lower SUDEP Rates

Graphic of a brain with arrow indicating lower SUDEP rates

1. Nair, et al., Neurology, 2020. 2. Sprengers et al., Cochrane Database of Systematic Reviews , 2017. 3. Voges et al., Epilepsia 2015; n=9 *N values are small and caution must be taken while interpreting results. 4. VNS Therapy® System Epilepsy Physician’s Manual, May 2020. 5. Tomson, T, et al., Lancet Neurology, 2008.

*Every individual’s seizures are different and results will vary.