The RNS® System delivers epilepsy treatment personalized to you.

Am I a candidate?

How It Works

The RNS System is a treatment for adults with drug-resistant focal epilepsy. Your doctor personalizes it to respond to your brain activity, delivering the treatment you need, when you need it.

What makes the RNS System so smart?

Monitors

It monitors brain activity continuously.

Recognizes & Responds

It is programmed to recognize a person’s unique seizure patterns, and automatically responds to prevent seizures before they start.

Records & Reports

It records and reports EEG data to help doctors personalize patient care.

Monitors

It monitors brain activity continuously.

Recognizes & Responds

It is programmed to recognize a person’s unique seizure patterns, and automatically responds to prevent seizures before they start.

Records & Reports

It records and reports EEG data to help doctors personalize patient care.

“The RNS System basically functions in the background for me. As I go about my daily life, I do not feel any physical or mental sensations from its electrical signals.”

Michael

Every person’s seizures are different and individual results will vary.

Fewer Seizures, More Living

In a real world study, RNS System patients reported experiencing fewer seizures.1

Significant Seizure Reduction

Median seizure frequency reduction at ≥3 years

More Seizure-free Days

~1 in 5 patients were seizure-free at their last check-up

Lower SUDEP Rate

SUDEP is the sudden, unexpected death of someone with epilepsy, who was otherwise healthy.2

Graphic of a brain with arrow indicating lower SUDEP rates

RNS System patients in a 9-year study showed a significantly lower SUDEP rate3

Improved Health and Wellness

In a clinical study of the RNS System, patients reported significant quality of life improvements.4

Improved Physical Health

Improved Mental Health

Less Seizure Worry

Improved Cognition

1. Razavi, et al. Epilepsia. 2020. 2. Epilepsy Foundation Website, 2021. 3. Nair, et al. Neurology 2020. Lower SUDEP rates relative to comparable refractory population. 4. Meador, et al. Epilepsy Behav. 2015

Important Safety Information

“I Would Do it Again”

Drew

Leona

Meaghan

Every person’s seizures are different and individual results will vary.

FAQs

Who is a candidate for the RNS System?

The RNS System is for individuals aged 18 and older who have tried at least 2 anti-seizure medications but still suffer from frequent and disabling focal (partial onset) seizures that come from one or two areas of the brain. Talk with your doctor to find out if the RNS System is right for you.

Will I be able to stop taking my anti-seizure medications?

The RNS System is considered a complementary treatment to your medications. Any change in your medications would be determined by your doctor.

When should I consider the RNS System?

Studies have shown that if you have tried two anti-seizure medications without achieving seizure control, there is a less than 5% chance that your seizures will be controlled on another medication. If you have failed two medications and still suffer from seizures, it may be time to ask your doctor about other treatment options, including the RNS System.

Chen, Z., et al. JAMA Neurology, 2018.

Is the RNS System covered by insurance?

The RNS System is broadly covered by most private and government insurance.

Can I expect to be seizure free?

Although you should not expect seizure freedom from the RNS System, a subset of patients report experiencing seizure-free periods.

In 9-year clinical study:

  • 35% of patients achieved ≥ 90% seizure frequency reduction*
  • 28% of patients had at least one ≥ 6 month period with no seizures

*during last 6 months of follow up, at 9 years
Nair, et al. Neurology, 2020.

What are the side effects of the RNS System?

The primary side effects associated with the RNS System are those that are related to any surgical procedure, such as risk of infection or bleeding. However, the RNS System does not cause the chronic side effects associated with many anti-seizure medications such as dizziness, drowsiness, depression, or confusion. It also does not have the ongoing stimulation-related side effects that can be associated with vagus nerve stimulation, such as hoarseness, shortness of breath, sore throat, or coughing. Consult with your doctor about the full risks and benefits of the RNS System and see the RNS System Safety Information.

LivaNova VNS Therapy System Epilepsy Physician’s Manual, May 2020. Heck, et al., Epilepsia, 2014.

Will I feel the stimulation?

When your doctor programs the device to the correct settings for you, you should not feel or notice stimulation. On average, the total amount of stimulation delivered by the RNS System adds up to approximately three minutes per day.

Nair, et al. Neurology, 2020.

Does the stimulation effect wear off?

No. Experience over many years shows seizure reduction continues to improve over time.

Nair, et al. Neurology, 2020.

Does the procedure involve brain surgery?

When doctors talk about epilepsy surgery, or brain surgery, they are often describing the removal of a portion of the brain that is causing your seizures. Similar to traditional epilepsy surgery, the RNS System targets the part of your brain that is causing the seizures. However, unlike epilepsy surgery, the surgical procedure to place the RNS System does not involve removing any brain tissue.

Where is the RNS System available?

The RNS System is currently available at most Comprehensive Epilepsy Centers (CECs) throughout the United States. CECs are specialized epilepsy centers that have a team of experts who can provide a complete evaluation for epilepsy patients, along with extensive medical, interventional, and surgical treatment options.

Find a Comprehensive Epilepsy Center near you